Identification of a human immunodominant T-cell epitope of mycobacterium tuberculosis antigen PPE44

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Construction of a Novel DNA Vaccine Candidate Encoding an HspX-PPE44-EsxV Fusion Antigen of Mycobacterium tuberculosis

Background: Mycobacterium tuberculosis is the causative agent of tuberculosis (TB). Bacille Calmette-Guerin (BCG) vaccine, is not effective in adults, therefore, many efforts have been made to produce an effective adult TB vaccine. The aim of this study was to develop a new tuberculosis DNA vaccine candidate encoding a recombinant HspX-PPE44-EsxV fusion antigen of M. tuberculosis. Methods: ...

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ژورنال

عنوان ژورنال: BMC Microbiology

سال: 2011

ISSN: 1471-2180

DOI: 10.1186/1471-2180-11-167